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Pirmitegravir

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Purity:99.86%

ee:99.4%

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COA CSFC HNMR HPLC LCMS ORP

Pirmitegravir

Catalog No. T39755Cas No. 2245231-10-9

Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection.

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Pack Size	Price	Availability
1 mg	$350	In Stock
5 mg	$970	In Stock
10 mg	$1,830	In Stock
25 mg	$2,270	In Stock
50 mg	$3,110	In Stock
100 mg	$4,670	In Stock

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Product Introduction

Bioactivity

Description	Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection.
In vitro	In CEMx174 cells, Pirmitegravir demonstrates an IC50 of 1.4 nM, inhibiting dual tropic HIV-189.6[1]. Pirmitegravir is a highly potent ALLINI, inhibiting both wild-type and Ral-resistant HIV-1 strains, with IC50 values ranging from picomolar to single-digit nanomolar[1].With an IC50 of 0.41 nM against HIV-1NL4-3, Pirmitegravir exhibits no observable cytotoxicity in human PBMCs at 10 μM (TC50 >10μM)[1].
In vivo	For once-daily administration, Pirmitegravir exhibits appropriate PK profiles[1]. The lack of micronucleus-inducing and bone marrow cell proliferation inhibitory potentials in rats (500, 1000, and 2000 mg/kg/day) supports the conclusion that Pirmitegravir is not genotoxic[1].An assessment of the Pharmacokinetics (PK) profile of Pirmitegravir in rat and dog has been conducted[1].
Alias	STP0404

Chemical Properties

Molecular Weight	495.01
Formula	C27H31ClN4O3
Cas No.	2245231-10-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (111.11 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0202 mL	10.1008 mL	20.2016 mL	101.0081 mL
5 mM	0.4040 mL	2.0202 mL	4.0403 mL	20.2016 mL
10 mM	0.2020 mL	1.0101 mL	2.0202 mL	10.1008 mL
20 mM	0.1010 mL	0.5050 mL	1.0101 mL	5.0504 mL
50 mM	0.0404 mL	0.2020 mL	0.4040 mL	2.0202 mL
100 mM	0.0202 mL	0.1010 mL	0.2020 mL	1.0101 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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