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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $813 | 35 days |
Description | PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively). |
Targets&IC50 | 5-HT1D receptor:6 nM (ki) |
In vitro | Compared with 84% for that of Sumatriptan, in a cytosensor cell-based assay, the intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT [1]. |
In vivo | PNU-142633 fails to alter resistance in these vascular beds. PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation [1]. |
Molecular Weight | 422.52 |
Formula | C24H30N4O3 |
Cas No. | 187665-65-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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