Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Punicalin

🥰Excellent
Catalog No. T4S1718Cas No. 65995-64-4

Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).

Punicalin

Punicalin

🥰Excellent
Purity: 99.95%
Catalog No. T4S1718Cas No. 65995-64-4
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).
Pack SizePriceAvailabilityQuantity
1 mg40 €In Stock
5 mg115 €In Stock
10 mg188 €In Stock
25 mg329 €In Stock
50 mg490 €In Stock
100 mg699 €In Stock
1 mL x 10 mM (in DMSO)187 €In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Punicalin"

Select Batch
Purity:99.95%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).
Targets&IC50
HIV-1:0.11 microg/ml
In vitro
The edema after carrageenan injection is believed to be biphasic in nature.?The initial phase, beginning 1 hr after carrageenan administration, is due to the release of histamine and serotonin.?The second phase occurs 2 to 5 hr after carrageenan administration.??is induced by the release of bradykinin, protease, prostaglandin and lysosome ?.?It has been reported that the second phase of edema is sensitive to most clinically effective anti-inflammatory agents, such as indomethacin.?However, that treatment with punicalagin and punicalin is effective against both phases of inflammation induced by carrageenan.
In vivo
Punicalagin and punicalin were the active components of T. catappa L., a hepatoprotective crude drug used in Southern Asia, and both found to exhibit great antioxidant activity and hepatoprotective effect on CC14- or acetaminophen-induced liver damages. Even if they had great antioxidant effects in smaller concentration in vitro, treatment with larger doses of punicalagin and punicalin yield liver cell damage in rats.?In studying their anti-inflammatory effects, similar results were also observed.
Animal Research
Edema in the left hind paw of rats was induced by injecting 0.05 ml of 1% (w/v) carrageenan into the limb.?Animals were divided into six groups with eight animals in each group.?The drug test groups were treated with 5 or 10 mg/kg body weight of each component 1 hr before carrageenan injection.?The animals in the control group received saline.?Another group of rats was administered 5 mg/kg indomethacin as a standard anti-inflammatory drug.
Chemical Properties
Molecular Weight782.53
FormulaC34H22O22
Cas No.65995-64-4
SmilesOC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c56)-c3c(O)c(O)c(O)cc3C(=O)OC2C(O)C1O
Relative Density.2.078g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (31.95 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2779 mL6.3895 mL12.7791 mL63.8953 mL
5 mM0.2556 mL1.2779 mL2.5558 mL12.7791 mL
10 mM0.1278 mL0.6390 mL1.2779 mL6.3895 mL
20 mM0.0639 mL0.3195 mL0.6390 mL3.1948 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Punicalin | purchase Punicalin | Punicalin cost | order Punicalin | Punicalin chemical structure | Punicalin in vivo | Punicalin in vitro | Punicalin formula | Punicalin molecular weight