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PXS-6302 hydrochloride
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.
Catalog No. T60438LCas No. 2584947-79-3
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Purity:99.89%
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PXS-6302 hydrochloride
Catalog No. T60438LCas No. 2584947-79-3
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 2 mg | $343 | In Stock | |
| 5 mg | $575 | In Stock | |
| 10 mg | $823 | In Stock | |
| 25 mg | $1,450 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,630 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars. |
| In vitro | PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells[1]. |
| In vivo | PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models[1]. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue[1]. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application[1]. |
| Alias | PXS-6302 hydrochloride （2584947-54-4 Free base） |
| Molecular Weight | 301.71 |
| Formula | C10H11ClF3NO2S |
| Cas No. | 2584947-79-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (165.72 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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