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Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
2 mg | $165 | In Stock | |
5 mg | $262 | In Stock | |
10 mg | $388 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $828 | In Stock | |
100 mg | $1,110 | In Stock | |
200 mg | $1,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $313 | In Stock |
Description | Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects. |
In vivo | Rapastinel acetate (3mg/kg; i.v.) facilitated long-term potentiation (LTP) 1day-2weeks but not 4weeks post-dosing. Biweekly dosing with Rapastinel acetate sustained this effect for at least 8weeks. A single dose of Rapastinel acetate increased the proportion of whole-cell NMDAR current contributed by NR2B-containing NMDARs in the hippocampus 1week post-dosing, which returned to baseline by 4weeks post-dosing[1]. |
Alias | Rapastinel acetate (117928-94-6 Free base) |
Molecular Weight | 473.52 |
Formula | C20H35N5O8 |
Cas No. | 491872-39-0 |
Smiles | C(C)(O)=O.C(=O)([C@H]1N(C([C@H]([C@@H](C)O)N)=O)CCC1)N2[C@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)CCC2 |
Relative Density. | no data available |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (47.52 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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