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Remogliflozin etabonate
Catalog No. T34286Cas No. 442201-24-3
Alias GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075
Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.
Remogliflozin etabonate
Catalog No. T34286Alias GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075Cas No. 442201-24-3
Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $88 | In Stock | |
| 25 mg | $167 | In Stock | |
| 50 mg | $257 | In Stock | |
| 100 mg | $358 | In Stock | |
| 200 mg | $497 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $56 | In Stock |
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Ertugliflozin L-pyroglutamic acid
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T152441210344-83-4
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM, suitable for studies on the treatment of type 2 diabetes mellitus.
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively. |
| Targets&IC50 | SGLT2 (rat):2.14 μM (Ki), SGLT1 (rat):8.57 μM (Ki), SGLT1 (human):43.1 μM (Ki), SGLT2 (human):1.95 μM (Ki) |
| In vivo | Oral administration of Remogliflozin etabonate (10-30 mg/kg) dose-dependently reduces the levels of FPG and GHb. Oral administration of Remogliflozin etabonate (3-30 mg/kg) dose-dependently increases urine volume and urinary glucose excretion[2]. |
| Alias | GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075 |
| Molecular Weight | 522.59 |
| Formula | C26H38N2O9 |
| Cas No. | 442201-24-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (172.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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