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RG-12915
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
Catalog No. T12716Cas No. 136174-04-4
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RG-12915
Catalog No. T12716Cas No. 136174-04-4
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM). |
| Targets&IC50 | 5-HT3:0.16 nM |
| In vitro | RG 12915 is a displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites with IC50 value of 0.16 nM, whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites (IC50 values less than 1 μM). |
| In vivo | RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species. RG 12915 has a lower ED50 value for attenuating cisplatin-induced emetic episodes in the ferret[1]. |
| Molecular Weight | 360.88 |
| Formula | C20H25ClN2O2 |
| Cas No. | 136174-04-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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