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RIPK1-IN-7

🥰Excellent
Catalog No. T12731Cas No. 2300982-44-7

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.

RIPK1-IN-7

RIPK1-IN-7

🥰Excellent
Purity: 98.02%
Catalog No. T12731Cas No. 2300982-44-7
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
Pack SizePriceAvailabilityQuantity
1 mg$93In Stock
5 mg$228In Stock
10 mg$347In Stock
25 mg$538In Stock
50 mg$745In Stock
100 mg$993In Stock
1 mL x 10 mM (in DMSO)$245In Stock
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Purity:98.02%
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Product Introduction

Bioactivity
Description
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
Targets&IC50
RIPK1:(kd)4 nM , RIPK1:11 nM
In vitro
In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).
Chemical Properties
Molecular Weight481.47
FormulaC25H22F3N5O2
Cas No.2300982-44-7
SmilesCCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
Relative Density.1.42 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (124.62 mM), Sonication is recommended.
H2O: 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0770 mL10.3849 mL20.7697 mL103.8486 mL
5 mM0.4154 mL2.0770 mL4.1539 mL20.7697 mL
10 mM0.2077 mL1.0385 mL2.0770 mL10.3849 mL
20 mM0.1038 mL0.5192 mL1.0385 mL5.1924 mL
50 mM0.0415 mL0.2077 mL0.4154 mL2.0770 mL
100 mM0.0208 mL0.1038 mL0.2077 mL1.0385 mL

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