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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $175 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $556 | In Stock | |
25 mg | $896 | In Stock | |
50 mg | $1,220 | In Stock | |
100 mg | $1,650 | In Stock | |
500 mg | $3,290 | In Stock | |
1 mL x 10 mM (in DMSO) | $393 | In Stock |
Description | RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. |
In vitro | In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively). |
Molecular Weight | 481.47 |
Formula | C25H22F3N5O2 |
Cas No. | 2300982-44-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (124.62 mM) H2O: 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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