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Rislenemdaz
🥰Excellent
Catalog No. T12733Cas No. 808732-98-1
Alias MK-0657, CERC-301
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
Rislenemdaz
🥰Excellent
Purity: 98.18%
Catalog No. T12733Alias MK-0657, CERC-301Cas No. 808732-98-1
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $313 | In Stock | |
| 10 mg | $496 | In Stock | |
| 25 mg | $828 | In Stock | |
| 50 mg | $1,150 | In Stock | |
| 100 mg | $1,550 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $345 | In Stock |
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Purity:98.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B). |
| Targets&IC50 | NMDAR 2B:3.6 nM, GluN2B:8.1 nM (ki), GluN2B:3.6 nM |
| In vitro | rislemdaz (CERC-301) inhibited calcium influx in agonist stimulated NMDA-GluN1a/GluN2B L(tk-) cells. rislemdaz (CERC-301) had an IC50 of 3.6 nM. rislemdaz is highly selective for GluN2B receptors. rislemdaz showed minimal activity against sigma-type receptors at a concentration of 10 uM[1]. |
| Alias | MK-0657, CERC-301 |
| Molecular Weight | 358.41 |
| Formula | C19H23FN4O2 |
| Cas No. | 808732-98-1 |
| Smiles | Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)[C@H](F)C2)cc1 |
| Relative Density. | 1.24 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (251.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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