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Ropinirole
🥰Excellent
Catalog No. T60418Cas No. 91374-21-9
Alias SKF101468, SKF 101468
Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease.
Ropinirole
🥰Excellent
Purity: 99.68%
Catalog No. T60418Alias SKF101468, SKF 101468Cas No. 91374-21-9
Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease. |
| Targets&IC50 | D2 receptor:29 nM (Ki), D2 receptor (human):7.4 (pEC50), D4 receptor (human):6.8 (pEC50), D3 receptor (human):8.4 (pEC50) |
| In vitro | Ropinirole has a 10- to 20-fold higher binding affinity for D3 receptors than for D2 and D4 receptors. As an orally potent D3/D2 receptor agonist, Ropinirole has a Ki value of 29 nM for the D2 receptor and has pEC50s of 7.4, 8.4, and 6.8 for the hD2, hD3, and hD4 receptors, respectively, with no affinity for the D1 receptor. [1] Ropinirole showed low activity at α2-adrenergic receptors and 5-HT2 receptors, but no activity at 5-HT1 receptors, benzodiazepine receptors, γ-aminobutyric acid receptors, and α1 and β-adrenergic receptors. [2] |
| In vivo | Intraperitoneal injections of Ropinirole at doses of 0.1-10 mg/kg were able to lower the threshold for intracranial self-stimulation (ICSS), showing anxiolytic and antidepressant effects without affecting motor function or spatial memory. [2] |
| Alias | SKF101468, SKF 101468 |
| Molecular Weight | 260.38 |
| Formula | C16H24N2O |
| Cas No. | 91374-21-9 |
| Smiles | O=C1NC2=CC=CC(=C2C1)CCN(CCC)CCC |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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