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Ropinirole

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Ropinirole

Catalog No. T60418Cas No. 91374-21-9

Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors. It is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor, which also has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has the potential for the treatment of Parkinson's disease[1] [2].

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Pack Size	Price	Availability
25 mg	$1,520	1-2 weeks
50 mg	$1,980	1-2 weeks
100 mg	$2,500	1-2 weeks

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Product Introduction

Bioactivity

Description	Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors. It is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor, which also has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has the potential for the treatment of Parkinson's disease[1] [2].
In vitro	Ropinirole has 10-20 times higher affinity for D 3 receptors than for D 2 and D 4 receptors. It is weakly active at α2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobu acid receptors or α1 and β-adrenoceptors [1] [2].
In vivo	Ropinirole, administered intraperitoneally at doses ranging from 0.1 to 10 mg/kg, effectively reduces intracranial self-stimulation thresholds and exhibits anxiolytic- and antidepressant-like properties, without impacting motor function or spatial memory [2].

Chemical Properties

Molecular Weight	260.37
Formula	C16H24N2O
Cas No.	91374-21-9

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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