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RORγt inverse agonist 13

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].

Catalog No. T9623Cas No. 2170477-75-3

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Purity:99%

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COA LCMS HNMR

RORγt inverse agonist 13

Catalog No. T9623Cas No. 2170477-75-3

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$118	In Stock
10 mg	$188	In Stock
25 mg	$328	In Stock
50 mg	$467	In Stock
100 mg	$636	In Stock
200 mg	$857	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Product Introduction

Bioactivity

Description	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].
Targets&IC50	RORγ:63.8 nM
In vitro	RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay[1].
In vivo	RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model[1].

Chemical Properties

Molecular Weight	513.29
Formula	C₂₃H₁₇Cl₂F₃N₂O₄
Cas No.	2170477-75-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mg/mL (19.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9482 mL	9.7411 mL	19.4822 mL	97.4108 mL
5 mM	0.3896 mL	1.9482 mL	3.8964 mL	19.4822 mL
10 mM	0.1948 mL	0.9741 mL	1.9482 mL	9.7411 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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