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RORγt inverse agonist 13
🥰Excellent
Catalog No. T9623Cas No. 2170477-75-3
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].
RORγt inverse agonist 13
🥰Excellent
Purity: 99%
Catalog No. T9623Cas No. 2170477-75-3
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $188 | In Stock | |
| 25 mg | $328 | In Stock | |
| 50 mg | $467 | In Stock | |
| 100 mg | $636 | In Stock | |
| 200 mg | $857 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1]. |
| Targets&IC50 | RORγ:63.8 nM |
| In vitro | RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay[1]. |
| In vivo | RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model[1]. |
| Molecular Weight | 513.29 |
| Formula | C23H17Cl2F3N2O4 |
| Cas No. | 2170477-75-3 |
| Smiles | OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1 |
| Relative Density. | 1.470 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (19.48 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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