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RP 70676

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Purity:98.89%

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COA HNMR LCMS

RP 70676

Catalog No. T12767Cas No. 136609-26-2

RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).

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Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$228	In Stock
10 mg	$347	In Stock
25 mg	$625	In Stock
50 mg	$878	In Stock
100 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Product Introduction

Bioactivity

Description	RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).
Targets&IC50	ACAT (rat):25 nM , ACAT (rabbit):44 nM
In vitro	RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.
In vivo	In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.

Chemical Properties

Molecular Weight	416.58
Formula	C25H28N4S
Cas No.	136609-26-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (300.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4005 mL	12.0025 mL	24.0050 mL	120.0250 mL
5 mM	0.4801 mL	2.4005 mL	4.8010 mL	24.0050 mL
10 mM	0.2400 mL	1.2002 mL	2.4005 mL	12.0025 mL
20 mM	0.1200 mL	0.6001 mL	1.2002 mL	6.0012 mL
50 mM	0.0480 mL	0.2400 mL	0.4801 mL	2.4005 mL
100 mM	0.0240 mL	0.1200 mL	0.2400 mL	1.2002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc