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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $67 | In Stock | |
10 mg | $115 | In Stock | |
25 mg | $238 | In Stock | |
50 mg | $362 | In Stock | |
100 mg | $543 | In Stock | |
200 mg | $653 | In Stock | |
1 mL x 10 mM (in DMSO) | $78 | In Stock |
Description | SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. |
In vitro | KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. It inhibits DNA-PK and PI-3K with greater potency in MCF7 than SW620 cell using cell-based assays. Five-day exposure to 1 mM KU-0060648 inhibits cell proliferation by more than 95% in MCF7 cells but only by 55% in SW620 cells. In clonogenic survival assays, KU-0060648 increases the cytotoxicity of etoposide and doxorubicin across the panel of DNA-PKcs-proficient cells, but not in DNA-PKcs-deficient cells, confirming that enhanced cytotoxicity of the topoisomerase II poisons etoposide and doxorubicin is due to DNA-PK inhibition. [1] |
Alias | SAR 131675 |
Molecular Weight | 358.39 |
Formula | C18H22N4O4 |
Cas No. | 1433953-83-3 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 70 mg/mL (195.32 mM) ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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