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SB 243213 dihydrochloride
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Catalog No. T12859LCas No. 1780372-25-9
SB 243213 dihydrochloride is an orally active, selective, and high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor, with a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor.
SB 243213 dihydrochloride
😃Good
Catalog No. T12859LCas No. 1780372-25-9
SB 243213 dihydrochloride is an orally active, selective, and high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor, with a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | 35 days | |
| 5 mg | $330 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB 243213 dihydrochloride is an orally active, selective, and high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor, with a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor. |
| Targets&IC50 | 5-HT2C receptor:9.37 (pki) |
| In vitro | SB 243213 dihydrochloride exhibits low affinity (pKi < 6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, and 5-HT7 receptors, weak affinity (pKi < 6.5) for cloned human 5-HT1D and D3 receptors, and moderate affinity (pKi = 6.7) for the cloned human D2 receptor. |
| In vivo | SB 243213 dihydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction. SB 243213 dihydrochloride (0.1-10 mg/kg; p.o.; 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |
| Molecular Weight | 501.33 |
| Formula | C22H21Cl2F3N4O2 |
| Cas No. | 1780372-25-9 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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