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SB 243213
🥰Excellent
Catalog No. T37816Cas No. 200940-22-3
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
SB 243213
🥰Excellent
Purity: 100%
Catalog No. T37816Cas No. 200940-22-3
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $538 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders. |
| Targets&IC50 | 5-HT7 receptor (human):5.64 (pKi), 5-HT2A receptor (human):7.01 (pKi), 5-HT2B receptor (human):7.2 (pKi), 5-HT6 receptor (human):6.5 (pKi) |
| In vitro | SB 243213 exhibits low affinity for cloned human 5-HT1D, 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, and 5-HT7 receptors[1]. |
| In vivo | In experimentally naive male Sprague-Dawley rats weighing 220-300 g, SB 243213 (0.1, 0.3, 1, 3, 10 mg/kg; oral administration; 1 hour pre-test) dose-dependently and significantly increased the duration of social interaction in brightly lit conditions and in an unfamiliar test box, lasting for 15 minutes[1]. |
| Molecular Weight | 428.41 |
| Formula | C22H19F3N4O2 |
| Cas No. | 200940-22-3 |
| Smiles | Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1C(F)(F)F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (233.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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