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SP-100030

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Purity:99.57%

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COA HPLC HNMR

SP-100030

Catalog No. T24816Cas No. 154563-54-9

SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA).

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$67	In Stock
10 mg	$106	In Stock
25 mg	$255	In Stock
50 mg	$397	In Stock
100 mg	$571	In Stock
500 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Product Introduction

Bioactivity

Description	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA).
In vitro	SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1]. ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2].
In vivo	SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].
Alias	SP100030, SP 100030

Chemical Properties

Molecular Weight	437.65
Formula	C14H5ClF9N3O
Cas No.	154563-54-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (114.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2849 mL	11.4247 mL	22.8493 mL	114.2465 mL
5 mM	0.4570 mL	2.2849 mL	4.5699 mL	22.8493 mL
10 mM	0.2285 mL	1.1425 mL	2.2849 mL	11.4247 mL
20 mM	0.1142 mL	0.5712 mL	1.1425 mL	5.7123 mL
50 mM	0.0457 mL	0.2285 mL	0.4570 mL	2.2849 mL
100 mM	0.0228 mL	0.1142 mL	0.2285 mL	1.1425 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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