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SR-3306
Catalog No. T16927Cas No. 1128096-91-2
SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight.
SR-3306
Catalog No. T16927Cas No. 1128096-91-2
SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $105 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $319 | In Stock | |
| 50 mg | $578 | In Stock | |
| 100 mg | $928 | In Stock | |
| 500 mg | $1,860 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $116 | In Stock |
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CitedSelect Batch
Purity:99.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight. |
| In vitro | METHODS: SR-3306 (0.001-100 μM) was used to treat cisplatin-resistant ovarian cancer cells to study its anticancer activity. RESULTS SR-3306 had inhibitory activity against cisplatin-resistant ovarian cancer cells, with an IC50 value of 0.05 μM. [4] |
| In vivo | METHODS: Dopaminergic neurons were labeled with antibodies against tyrosine hydroxylase (TH) in brain sections from rats treated with 6-OHDA. Rats received SR-3306 (2.5 mg/kg, 10 mg/kg, subcutaneously, for 14 days). The ability of SR-3306 to prevent nigrostriatal neuronal loss was examined in the 6-OHDA model. RESULTS 6-OHDA-lesioned rats treated with 2.5 mg/kg SR-3306 showed a slight increase in ipsilateral TH-positive neurons, and 10 mg/kg SR-3306 had a significant protective effect against 6-OHDA-induced neurodegeneration when the contralateral side was compared with the ipsilateral side. [1] METHODS: Wild-type lean mice were given SR3306 (30, 60 mg/kg, intraperitoneal injection) to study the effects of SR3306 on food intake and energy balance. RESULTS 30 mg/kg of SR3306 did not affect saccharin intake preference, while a dose of 60 mg/kg produced a strong avoidance response to saccharin. [2] |
| Molecular Weight | 490.56 |
| Formula | C28H26N8O |
| Cas No. | 1128096-91-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (254.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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