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T-3775440 hydrochloride

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Purity:99.94%

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COA HNMR HPLC

T-3775440 hydrochloride

Catalog No. T13055Cas No. 1422535-52-1

T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$263	In Stock
10 mg	$393	In Stock
25 mg	$658	In Stock
50 mg	$937	In Stock
100 mg	$1,270	In Stock
1 mL x 10 mM (in DMSO)	$257	In Stock

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Product Introduction

Bioactivity

Description	T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
In vitro	T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. Knockdown of LSD1 and GFI1B recapitulated T-3775440-induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1-GFI1B axis inhibition with regard to the anti-AML effects of T-3775440[1].
In vivo	T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models[1].

Chemical Properties

Molecular Weight	346.85
Formula	C18H23ClN4O
Cas No.	1422535-52-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.18 mg/mL (87.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8831 mL	14.4155 mL	28.8309 mL	144.1545 mL
5 mM	0.5766 mL	2.8831 mL	5.7662 mL	28.8309 mL
10 mM	0.2883 mL	1.4415 mL	2.8831 mL	14.4155 mL
20 mM	0.1442 mL	0.7208 mL	1.4415 mL	7.2077 mL
50 mM	0.0577 mL	0.2883 mL	0.5766 mL	2.8831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc