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T0070907

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Purity:99.95%

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COA HPLC HNMR

T0070907

Catalog No. T6689Cas No. 313516-66-4

T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.

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Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$53	In Stock
25 mg	$93	In Stock
50 mg	$150	In Stock
100 mg	$207	In Stock
200 mg	$269	In Stock
500 mg	$453	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
Targets&IC50	PPARγ:1 nM
In vivo	T0070907 can attenuate the beneficial effects of lipopolysaccharide pretreatment, such as significantly improving renal insufficiency, reducing hepatocyte damage and circulatory failure, and reducing plasma interleukin-1 elevation caused by severe endotoxemia.
Kinase Assay	Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ.
Cell Research	MTS assay(Only for Reference)

Chemical Properties

Molecular Weight	277.66
Formula	C12H8ClN3O3
Cas No.	313516-66-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (180.08 mM)

1eq. HCl: 27.8 mg/mL (100 mM)

Solution Preparation Table

1eq. HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6015 mL	18.0076 mL	36.0153 mL	180.0764 mL
5 mM	0.7203 mL	3.6015 mL	7.2031 mL	36.0153 mL
10 mM	0.3602 mL	1.8008 mL	3.6015 mL	18.0076 mL
20 mM	0.1801 mL	0.9004 mL	1.8008 mL	9.0038 mL
50 mM	0.0720 mL	0.3602 mL	0.7203 mL	3.6015 mL
100 mM	0.0360 mL	0.1801 mL	0.3602 mL	1.8008 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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