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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $45 | In Stock | |
10 mg | $53 | In Stock | |
25 mg | $93 | In Stock | |
50 mg | $150 | In Stock | |
100 mg | $207 | In Stock | |
200 mg | $269 | In Stock | |
500 mg | $453 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ. |
Targets&IC50 | PPARγ:1 nM |
In vivo | T0070907 can attenuate the beneficial effects of lipopolysaccharide pretreatment, such as significantly improving renal insufficiency, reducing hepatocyte damage and circulatory failure, and reducing plasma interleukin-1 elevation caused by severe endotoxemia. |
Kinase Assay | Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ. |
Cell Research | MTS assay(Only for Reference) |
Molecular Weight | 277.66 |
Formula | C12H8ClN3O3 |
Cas No. | 313516-66-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (180.08 mM) ![]() 1eq. HCl: 27.8 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
1eq. HCl/DMSO
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