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Tagitinin C
🥰Excellent
Catalog No. T124580Cas No. 59979-56-5
Tagitinin C is a sesquiterpene compound derived from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity. It induces ferroptosis through the PERK-Nrf2-HO-1 signaling pathway.
Tagitinin C
🥰Excellent
Catalog No. T124580Cas No. 59979-56-5
Tagitinin C is a sesquiterpene compound derived from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity. It induces ferroptosis through the PERK-Nrf2-HO-1 signaling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $298 | In Stock | |
| 5 mg | $728 | In Stock | |
| 10 mg | $1,168 | In Stock | |
| 25 mg | $2,189 | In Stock | |
| 50 mg | $3,270 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tagitinin C is a sesquiterpene compound derived from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity. It induces ferroptosis through the PERK-Nrf2-HO-1 signaling pathway. |
| Targets&IC50 | U373:6.1 μg/mL, Hep-G2 CELL:2.0 μg/mL |
| In vitro | Tagitinin C can inhibit the proliferation of human glioblastoma U373, IC50 = 6.1±0.1 μg /mL. [1] Tagitinin C has cytotoxic activity against human hepatocellular carcinoma Hep-G2 cells with IC (50) = 2.0 ± 0.1 μg/mL. [2] Tagitinin C induces iron death through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway. It can be used as a new inducer of iron death. [3] |
| In vivo | Tagitinin C (15 μg/ mouse/day) delayed tumorigenicity in Hep-G2 cell xenografts. [2] |
| Molecular Weight | 348.39 |
| Formula | C19H24O6 |
| Cas No. | 59979-56-5 |
| Smiles | C/C/1=C/[C@@H]2[C@@H]([C@@H](C[C@@](/C=C\C1=O)(C)O)OC(=O)C(C)C)C(=C)C(=O)O2 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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