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TDZD-8

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Purity:99.48%

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COA HNMR LCMS

TDZD-8

Catalog No. T6187Cas No. 327036-89-5

TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

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Pack Size	Price	Availability
5 mg	$42	In Stock
10 mg	$53	In Stock
25 mg	$77	In Stock
50 mg	$126	In Stock
100 mg	$198	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Product Introduction

Bioactivity

Description	TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
In vitro	TDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. [1] TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens. [2]
Alias	GSK-3β Inhibitor I, NP 01139

Chemical Properties

Molecular Weight	222.26
Formula	C10H10N2O2S
Cas No.	327036-89-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 70 mg/mL (314.95 mM)

Ethanol: 44.5 mg/mL (200.21 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.4992 mL	22.4962 mL	44.9924 mL	224.9618 mL
5 mM	0.8998 mL	4.4992 mL	8.9985 mL	44.9924 mL
10 mM	0.4499 mL	2.2496 mL	4.4992 mL	22.4962 mL
20 mM	0.2250 mL	1.1248 mL	2.2496 mL	11.2481 mL
50 mM	0.0900 mL	0.4499 mL	0.8998 mL	4.4992 mL
100 mM	0.0450 mL	0.2250 mL	0.4499 mL	2.2496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc