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Thiethylperazine
Catalog No. T61915Cas No. 1420-55-9
Alias Tietilperazina
Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases.
Thiethylperazine
Catalog No. T61915Alias TietilperazinaCas No. 1420-55-9
Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 5 mg | $83 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $218 | In Stock | |
| 50 mg | $325 | In Stock | |
| 100 mg | $483 | In Stock | |
| 500 mg | $1,080 | In Stock |
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Purity:98.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases. |
| In vitro | Thiethylperazine enhances the activity of the antibiotic vancomycin at concentrations as low as 2 μg/mL, and it inhibits vancomycin-sensitive and -resistant Enterococcus strains with MIC values of 8 μg/mL, 16 μg/mL, and 8 μg/mL, respectively[3]. |
| In vivo | Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) markedly decreases Aβ42 levels in young APP/PS1 mice, utilizing an animal model comprising young mice genetically modified to express the amyloid precursor protein (APPswe) and mutant presenilin-1 (PS1) [2], demonstrating a significant reduction in Aβ42 levels and offering insights into potential therapeutic approaches for Alzheimer's disease. |
| Alias | Tietilperazina |
| Molecular Weight | 399.62 |
| Formula | C22H29N3S2 |
| Cas No. | 1420-55-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (200.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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