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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $96 | In Stock | |
5 mg | $239 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $655 | In Stock | |
50 mg | $918 | In Stock | |
100 mg | $1,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $258 | In Stock |
Description | TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1. |
In vitro | TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.?Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators. |
Molecular Weight | 371.84 |
Formula | C18H14ClN3O2S |
Cas No. | 326921-25-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (80.68 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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