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TNG908
🥰Excellent
Catalog No. T73494Cas No. 2760481-53-4
TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.
TNG908
🥰Excellent
Purity: 99.79%
Catalog No. T73494Cas No. 2760481-53-4
TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $313 | In Stock | |
| 5 mg | $679 | In Stock | |
| 10 mg | $1,060 | In Stock | |
| 25 mg | $1,650 | In Stock | |
| 50 mg | $2,180 | In Stock | |
| 100 mg | $2,800 | In Stock |
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CitedSelect Batch
Purity:99.79%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers. |
| Targets&IC50 | PRMT5:0.009μM |
| In vitro | In SDMA, HAP1 MTAP WT, and MTAP-null In-Cell, treatment with TNG908 (0-10μM; 24 hours) resulted in an IC50 value of 0.009μM for PRMT5[1]. |
| In vivo | TNG908 (1-120 mg/kg, p.o. or i.v.) demonstrates dose-dependent, MTAPnull-selective antitumor activity in xenograft models[1]. |
| Molecular Weight | 409.51 |
| Formula | C21H23N5O2S |
| Cas No. | 2760481-53-4 |
| Smiles | C(C(NC=1C=C(C)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC=N4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (195.36 mM), Sonification is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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