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Trifluoromethyl-tubercidin

Trifluoromethyl-tubercidin
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Purity:100%
ee:99.96%

Trifluoromethyl-tubercidin

Catalog No. T67753Cas No. 1854086-05-7
Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity.
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Pack SizePriceAvailabilityQuantity
1 mg$329In Stock
5 mg$798In Stock
10 mg$1,090In Stock
25 mg$1,650In Stock
50 mg$2,230In Stock
100 mg$2,930In Stock
1 mL x 10 mM (in DMSO)$898In Stock
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Product Introduction

Bioactivity
Description
Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity.
In vitro
The median inhibitory concentration (IC50) for trifluoromethyl-tubercidin against IAV infection was 0.30 μM, and no notable in vitro toxicity was observed in the range of effective concentrations, as measured with water-soluble tetrazolium (WST)–8 cell viability assay. Trifluoromethyl-tubercidin treatment also greatly inhibited IAV replication when administered 3 to 4 hours after infection. Trifluoromethyl-tubercidin showed inhibitory activity in the IAV-infected mouse cell line LA-4, albeit with lower potency (IC50 = 7.7 μM) than in human cells[1].
In vivo
Trifluoromethyl-tubercidin treatment at 2 days after infection with IAV. At this point, NP and PB2 mRNA levels were significantly reduced by trifluoromethyl-tubercidin treatment in mouse lungs, indicating that the trifluoromethyl substitution of tubercidin reduces in vivo toxicity to levels we could not detect, but retains anti-IAV efficacy[1].
Chemical Properties
Molecular Weight334.25
FormulaC12H13F3N4O4
Cas No.1854086-05-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 3.34 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9918 mL14.9589 mL29.9177 mL149.5886 mL
5 mM0.5984 mL2.9918 mL5.9835 mL29.9177 mL

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