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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $329 | In Stock | |
5 mg | $798 | In Stock | |
10 mg | $1,090 | In Stock | |
25 mg | $1,650 | In Stock | |
50 mg | $2,230 | In Stock | |
100 mg | $2,930 | In Stock | |
1 mL x 10 mM (in DMSO) | $898 | In Stock |
Description | Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity. |
In vitro | The median inhibitory concentration (IC50) for trifluoromethyl-tubercidin against IAV infection was 0.30 μM, and no notable in vitro toxicity was observed in the range of effective concentrations, as measured with water-soluble tetrazolium (WST)–8 cell viability assay. Trifluoromethyl-tubercidin treatment also greatly inhibited IAV replication when administered 3 to 4 hours after infection. Trifluoromethyl-tubercidin showed inhibitory activity in the IAV-infected mouse cell line LA-4, albeit with lower potency (IC50 = 7.7 μM) than in human cells[1]. |
In vivo | Trifluoromethyl-tubercidin treatment at 2 days after infection with IAV. At this point, NP and PB2 mRNA levels were significantly reduced by trifluoromethyl-tubercidin treatment in mouse lungs, indicating that the trifluoromethyl substitution of tubercidin reduces in vivo toxicity to levels we could not detect, but retains anti-IAV efficacy[1]. |
Molecular Weight | 334.25 |
Formula | C12H13F3N4O4 |
Cas No. | 1854086-05-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 3.34 mg/mL (10 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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