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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $163 | In Stock | |
25 mg | $278 | In Stock | |
50 mg | $372 | In Stock | |
100 mg | $488 | In Stock | |
500 mg | $1,060 | In Stock | |
1 mL x 10 mM (in DMSO) | $118 | In Stock |
Description | TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39). It shows higher affinity for FFAR1 or GPR40 relative to related receptors FFA2, FFA3, and the nuclear receptor PPARγ, as well as various other receptors, ion channels, and transporter proteins. TUG-499 is useful for studying Type 2 diabetes. |
Targets&IC50 | FFAR1/GPR40:7.39(pEC50) |
In vitro | TUG-499 exhibits remarkable chemical stability, does not inhibit specific CYP enzymes or P-glycoprotein, and displays outstanding Caco-2 permeability. Its potent effects are observed on recombinant human FFA1 receptors as well as the INS-1E rat insulinoma cell line.[1] |
Molecular Weight | 320.17 |
Formula | C16H11Cl2NO2 |
Cas No. | 1206629-08-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (70.28 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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