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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $56 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $428 | In Stock | |
1 mL x 10 mM (in DMSO) | $62 | In Stock |
Description | Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively) |
In vivo | Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats |
Molecular Weight | 445.53 |
Formula | C26H28FN5O |
Cas No. | 705946-27-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 62.5 mg/mL (160.47 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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