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U18666A

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Purity:99.83%

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COA HPLC HNMR

U18666A

Catalog No. T17190Cas No. 3039-71-2

U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$195	In Stock
50 mg	$339	In Stock
100 mg	$538	In Stock
200 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description	U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.
In vitro	U18666A, the antiviral effect is found to result from retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppressed de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor [1][2].

Chemical Properties

Molecular Weight	424.06
Formula	C25H42ClNO2
Cas No.	3039-71-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (23.58 mM)

DMSO: 50 mg/mL (117.91 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3582 mL	11.7908 mL	23.5816 mL	117.9078 mL
5 mM	0.4716 mL	2.3582 mL	4.7163 mL	23.5816 mL
10 mM	0.2358 mL	1.1791 mL	2.3582 mL	11.7908 mL
20 mM	0.1179 mL	0.5895 mL	1.1791 mL	5.8954 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0472 mL	0.2358 mL	0.4716 mL	2.3582 mL
100 mM	0.0236 mL	0.1179 mL	0.2358 mL	1.1791 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc