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UC-1728

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Purity:99.88%

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COA HNMR HPLC

UC-1728

Catalog No. T17196Cas No. 948304-40-3

UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).

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Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$106	In Stock
25 mg	$197	In Stock
50 mg	$328	In Stock
100 mg	$569	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock

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Product Introduction

Bioactivity

Description	UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
Targets&IC50	sHE (rabbit):2 nM
In vivo	Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system.?Eyes treated by intra-cameral injection of PBS, or by aseptic preparation served as further controls.?Signs of inflammation in this model were mild and transient.?Treatment with UC1728 did not significantly reduce inflammation compared to animals treated with the PEG400 vehicle.?Blood levels of UC1728 were a thousand fold higher than the in vitro determined inhibitory potency (IC50) of the compound suggesting a significant degree of inhibition of sEH in the rabbit.?The lack of efficacy suggests that sEH or its substrates the EETs may not be involved in mediating inflammation in this model of uveitis[1].
Alias	t-TUCB

Chemical Properties

Molecular Weight	438.4
Formula	C21H21F3N2O5
Cas No.	948304-40-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (45.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2810 mL	11.4051 mL	22.8102 mL	114.0511 mL
5 mM	0.4562 mL	2.2810 mL	4.5620 mL	22.8102 mL
10 mM	0.2281 mL	1.1405 mL	2.2810 mL	11.4051 mL
20 mM	0.1141 mL	0.5703 mL	1.1405 mL	5.7026 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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