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UCM05

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Purity:99.11%

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COA HNMR HPLC

UCM05

Catalog No. T21831Cas No. 1094451-90-7

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including in cell lines resistant to anti-HER2 drugs [1]. Additionally, it functions as an inhibitor of the Filamentous temperature-sensitive protein Z (FtsZ), selectively inhibiting the growth of the Gram-positive bacterium B. subtilis with minimum inhibitory concentration (MIC) values of 100 μM, while showing no activity against the Gram-negative bacterium E. coli [2].

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$139	In Stock
25 mg	$289	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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Product Introduction

Bioactivity

Description	UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including in cell lines resistant to anti-HER2 drugs [1]. Additionally, it functions as an inhibitor of the Filamentous temperature-sensitive protein Z (FtsZ), selectively inhibiting the growth of the Gram-positive bacterium B. subtilis with minimum inhibitory concentration (MIC) values of 100 μM, while showing no activity against the Gram-negative bacterium E. coli [2].
In vitro	G28UCM shows cytotoxic activity in developed HER2 + and FASN + trastuzumab and lapatinib-resistant cells[1].
In vivo	G28UCM (40 mg/Kg; Daily i.p; for 45 days) inhibits the growth of BT474 xenografts and do not induce weight loss in vivo[1].
Alias	G28UCM

Chemical Properties

Molecular Weight	464.38
Formula	C24H16O10
Cas No.	1094451-90-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (193.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1534 mL	10.7670 mL	21.5341 mL	107.6704 mL
5 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL
20 mM	0.1077 mL	0.5384 mL	1.0767 mL	5.3835 mL
50 mM	0.0431 mL	0.2153 mL	0.4307 mL	2.1534 mL
100 mM	0.0215 mL	0.1077 mL	0.2153 mL	1.0767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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