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UCM05

Catalog No. T21831   CAS 1094451-90-7
Synonyms: G28UCM

UCM05 (G28UCM) (G28UCM) is a potent fatty acid synthase ( FASN ) inhibitor that shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines [1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli [2].

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UCM05 Chemical Structure
UCM05, CAS 1094451-90-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 80.00
10 mg In stock $ 139.00
25 mg In stock $ 289.00
50 mg In stock $ 455.00
100 mg In stock $ 672.00
1 mL * 10 mM (in DMSO) In stock $ 82.00
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Purity: 99.11%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description UCM05 (G28UCM) (G28UCM) is a potent fatty acid synthase ( FASN ) inhibitor that shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines [1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli [2].
In vitro G28UCM shows cytotoxic activity in developed HER2 + and FASN + trastuzumab and lapatinib-resistant cells[1].
In vivo G28UCM (40 mg/Kg; Daily i.p; for 45 days) inhibits the growth of BT474 xenografts and do not induce weight loss in vivo[1].
Synonyms G28UCM
Molecular Weight 464.38
Formula C24H16O10
CAS No. 1094451-90-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (193.8 mM), sonification is recommended.

TargetMolReferences and Literature

1. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131. 2. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Compound Library Inhibitor Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Obesity Compound Library

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Keywords

UCM05 1094451-90-7 Metabolism Fatty Acid Synthase UCM-05 G28UCM UCM 05 inhibitor inhibit

 

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