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Vernakalant Hydrochloride

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Purity:99.04%

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COA HPLC HNMR

Vernakalant Hydrochloride

Catalog No. T17227Cas No. 748810-28-8

Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.

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Pack Size	Price	Availability
1 mg	$68	In Stock
2 mg	$98	In Stock
5 mg	$178	In Stock
10 mg	$289	In Stock
25 mg	$551	In Stock
50 mg	$793	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

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Product Introduction

Bioactivity

Description	Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
Targets&IC50	Kv1.5 channel (WT):13.35±0.93 μM, Kv1.5 channel (T479A):1.63±0.09 μM, I508F:0.61±0.03 μM
In vitro	Block of Kv1.5 by Vernakalant Hydrochloride occurs after channel activation, as Vernakalant induces a rapid block of channel current upon depolarization with minimal resting or “tonic” block. The most significant effect is the reduction in potency at I502A, with an IC50 of 329±19 μM (n=4-10) compared to a control IC50 of 13.4±0.9 μM (n=5-23), reflecting a 25-fold potency decrease. Lesser reductions in potency, between 3- and 4-fold, were noted for V505A, I508A, T480A, and C500A. For wild-type and mutant Kv1.5 channels, IC50 for Vernakalant block are 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channels, Kv1.5 channelI508F, and Kv1.5 channelT479A, respectively [1].
Alias	RSD1235 hydrochloride

Chemical Properties

Molecular Weight	385.93
Formula	C20H32ClNO4
Cas No.	748810-28-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (116.6 mM), Sonication is recommended.

H2O: 45 mg/mL (116.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5911 mL	12.9557 mL	25.9114 mL	129.5572 mL
5 mM	0.5182 mL	2.5911 mL	5.1823 mL	25.9114 mL
10 mM	0.2591 mL	1.2956 mL	2.5911 mL	12.9557 mL
20 mM	0.1296 mL	0.6478 mL	1.2956 mL	6.4779 mL
50 mM	0.0518 mL	0.2591 mL	0.5182 mL	2.5911 mL
100 mM	0.0259 mL	0.1296 mL	0.2591 mL	1.2956 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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