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Vernakalant Hydrochloride
🥰Excellent
Catalog No. T17227Cas No. 748810-28-8
Alias RSD1235 hydrochloride
Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
Vernakalant Hydrochloride
🥰Excellent
Purity: 99.04%
Catalog No. T17227Alias RSD1235 hydrochlorideCas No. 748810-28-8
Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 2 mg | $98 | In Stock | |
| 5 mg | $178 | In Stock | |
| 10 mg | $289 | In Stock | |
| 25 mg | $551 | In Stock | |
| 50 mg | $793 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
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Purity:99.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. |
| Targets&IC50 | Kv1.5 channel (T479A):1.63±0.09 μM, I508F:0.61±0.03 μM, Kv1.5 channel (WT):13.35±0.93 μM |
| In vitro | Block of Kv1.5 by Vernakalant Hydrochloride occurs after channel activation, as Vernakalant induces a rapid block of channel current upon depolarization with minimal resting or “tonic” block. The most significant effect is the reduction in potency at I502A, with an IC50 of 329±19 μM (n=4-10) compared to a control IC50 of 13.4±0.9 μM (n=5-23), reflecting a 25-fold potency decrease. Lesser reductions in potency, between 3- and 4-fold, were noted for V505A, I508A, T480A, and C500A. For wild-type and mutant Kv1.5 channels, IC50 for Vernakalant block are 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channels, Kv1.5 channelI508F, and Kv1.5 channelT479A, respectively [1]. |
| Alias | RSD1235 hydrochloride |
| Molecular Weight | 385.93 |
| Formula | C20H32ClNO4 |
| Cas No. | 748810-28-8 |
| Smiles | Cl.COc1ccc(CCO[C@@H]2CCCC[C@H]2N2CC[C@@H](O)C2)cc1OC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (116.6 mM), Sonication is recommended. H2O: 45 mg/mL (116.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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