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VU591 hydrochloride

VU591 hydrochloride
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Purity:99.95%
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VU591 hydrochloride

Catalog No. T13320Cas No. 1315380-70-1
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590
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Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$113In Stock
10 mg$189In Stock
25 mg$396In Stock
50 mg$679In Stock
100 mg$948In Stock
1 mL x 10 mM (in DMSO)$126In Stock
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Product Introduction

Bioactivity
Description
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibi
Targets&IC50
ROMK:0.24 μM
Chemical Properties
Molecular Weight404.76
FormulaC16H13ClN6O5
Cas No.1315380-70-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.33 mg/mL (10.71 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4706 mL12.3530 mL24.7060 mL123.5300 mL
5 mM0.4941 mL2.4706 mL4.9412 mL24.7060 mL
10 mM0.2471 mL1.2353 mL2.4706 mL12.3530 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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