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XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be used in the study of acute myelogenous leukaemia (AML).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $93 | In Stock | |
10 mg | $148 | In Stock | |
25 mg | $297 | In Stock | |
50 mg | $497 | In Stock | |
100 mg | $693 | In Stock | |
500 mg | $1,450 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be used in the study of acute myelogenous leukaemia (AML). |
Targets&IC50 | AML:870 nM-2.3 μM |
In vitro | During split Renilla luciferase complementation analysis, XX-650-23 exhibited an IC50 of 3.20 ± 0.43 μM in inhibiting the interaction between CREB and CBP [1]. Following treatment with XX-650-23 (100 pM - 10 μM) for 48 hours, four AML cell lines showed IC50 values ranging from 870 nM to 2.3 μM, defined as a 50% reduction in viable cell count compared to DMSO-treated cells, indicating the inhibition of AML growth by XX-650-23 [1]. |
In vivo | XX-650-23 (2.3 mg/kg, intravenous injection) extends the survival of AML mouse model (NSG mice) and exhibits no toxicity[1]. |
Alias | XX65023, XX 650 23 |
Molecular Weight | 288.3 |
Formula | C18H12N2O2 |
Cas No. | 117739-40-9 |
Smiles | N#CC1=CC=C(C=C1)NC(=O)C2=CC=3C=CC=CC3C=C2O |
Relative Density. | 1.36 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (277.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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