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Zinc Protoporphyrin
🥰Excellent
Catalog No. T13396Cas No. 15442-64-5
Alias ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.
Zinc Protoporphyrin
🥰Excellent
Purity: 99.27%
Catalog No. T13396Alias ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9Cas No. 15442-64-5
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $49 | In Stock | |
| 10 mg | Inquiry | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $77 | In Stock |
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Purity:99.27%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity. |
| In vitro | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) increased the proportion of late apoptosis and necrotic cells from 10.9% in the control group to 30.4% after 72 hours [3]. Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells[3]. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle[3]. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3[3]. |
| In vivo | Zinc Protoporphyrin exhibits dose-dependent antitumor effects manifested by the retardation of tumor growth[3]. |
| Alias | ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9 |
| Molecular Weight | 626.02 |
| Formula | C34H32N4O4Zn |
| Cas No. | 15442-64-5 |
| Smiles | CC1=C(CCC(O)=O)C2=N\C\1=C/c1c(C=C)c(C)c3\C=C4/N=C(/C=c5/c(C)c(CCC(O)=O)\c(=C\2)n5[Zn]n13)C(C)=C4C=C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (79.87 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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