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δ-secretase inhibitor 11
🥰Excellent
Catalog No. T9713Cas No. 842964-18-5
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
δ-secretase inhibitor 11
🥰Excellent
Purity: 99.4%
Catalog No. T9713Cas No. 842964-18-5
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 28 € | In Stock | |
| 10 mg | 40 € | In Stock | |
| 25 mg | 92 € | In Stock | |
| 50 mg | 158 € | In Stock | |
| 100 mg | 236 € | In Stock |
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Purity:99.4%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. |
| In vitro | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1]. |
| In vivo | It was found that oral administration of δ-secretase inhibitor 11 (10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
| Molecular Weight | 220.23 |
| Formula | C10H12N4O2 |
| Cas No. | 842964-18-5 |
| Smiles | Nc1ccc(N2CCOCC2)c2nonc12 |
| Relative Density. | 1.390 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.2 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
δ-Secretase inhibitor 11δ-secretase inhibitor 11δsecretase inhibitor 11δ secretase inhibitor 11β-amyloid peptideβAmyloidβ AmyloidPala cellsoxygen-glucose deprivationInhibitorinhibitdelta-secretase inhibitor 11CNS diseasesCaspaseBetaAmyloidBeta AmyloidbAmyloidb Amyloidasparagine endopeptidaseAPPamyloid-βAmyloid-βamyloid precursor proteinAlzheimer's diseaseAEPAbeta
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