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(RS)-(Tetrazol-5-yl)glycine

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Purity:95.00%

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COA LCMS HNMR

(RS)-(Tetrazol-5-yl)glycine

Catalog No. T16801Cas No. 138199-51-6

(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively.

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Pack Size	Price	Availability
5 mg	$60	In Stock
10 mg	$97	In Stock
25 mg	$238	In Stock
50 mg	$411	In Stock
100 mg	$590	In Stock

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Product Introduction

Bioactivity

Description	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively.
In vitro	(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1].
In vivo	(RS)-(Tetrazol-5-yl)glycine is a potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.). (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) causes seizure responses and Fos in the NR1+/+ and NR1-/- mice [1][3].
Alias	LY 285265, D,L-(tetrazol-5-yl)glycine

Chemical Properties

Molecular Weight	143.1
Formula	C3H5N5O2
Cas No.	138199-51-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9881 mL	34.9406 mL	69.8812 mL	349.4060 mL
5 mM	1.3976 mL	6.9881 mL	13.9762 mL	69.8812 mL

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