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ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $365 | In Stock | |
5 mg | $877 | In Stock | |
10 mg | $1,180 | In Stock | |
25 mg | $1,790 | In Stock | |
50 mg | $2,390 | In Stock | |
100 mg | $3,250 | In Stock |
Description | ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA. |
Targets&IC50 | α1A:1.2 μM, M2:2 μM, ERG (human):33 μM, Pf:9 nM |
In vitro | ZY-19489 showed the best potency (9 nM) combined with a >1,000-fold selectivity against hERG and AChE compared.[1] 12 displayed improved bioavailability (80%) as compared with its demethylated analog, 9 owing to its improved Caco2 permeability.[1] |
Molecular Weight | 465.57 |
Formula | C24H32FN9 |
Cas No. | 1821293-40-6 |
Smiles | N(C=1C(=CN=C(NC2=CC(=C(F)C(C)=N2)C3CC3)N1)N4C[C@@H](C)N(C)CC4)C=5C=C(C)N(C)N5 |
Relative Density. | 1.38 g/cm3 (Predicted) |
Storage | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.66 mg/mL (10 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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