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2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $43 | In Stock | |
5 mg | $100 | In Stock | |
10 mg | $165 | In Stock | |
25 mg | $315 | In Stock | |
50 mg | $489 | In Stock | |
100 mg | $759 | In Stock | |
200 mg | $987 | In Stock |
Description | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile. |
Targets&IC50 | JAK2:0.7 nM (Ki), JAK1:0.7 nM (Ki), TYK2:4.8 nM (Ki), JAK3:0.4 nM (Ki) |
Alias | GDC046 |
Molecular Weight | 350.2 |
Formula | C16H13Cl2N3O2 |
Cas No. | 1258292-64-6 |
Smiles | Clc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 3.5 mg/mL (9.99 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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