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MNK8
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].
Catalog No. T9945Cas No. 2055078-49-2
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Purity:99.74%
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MNK8
Catalog No. T9945Alias 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dioneCas No. 2055078-49-2
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $93 | In Stock | |
| 25 mg | $173 | In Stock | |
| 50 mg | $237 | In Stock | |
| 100 mg | $355 | In Stock | |
| 500 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $56 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1]. |
| In vitro | MNK8, at a concentration of 50 μM over a period of 0 to 48 hours, resulted in a time-dependent increase in Sub-G1 cells and concurrently led to a reduction in the levels of antiapoptotic proteins, namely Bcl-2, survivin, and cyclin D1 [1]. |
| Alias | 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione |
| Molecular Weight | 252.27 |
| Formula | C15H12N2O2 |
| Cas No. | 2055078-49-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (218.02 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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