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5-Feruloylquinic acid

Catalog No. TN1296Cas No. 40242-06-6
Alias 5-O-Feruloylquinic acid, 5-FQA

5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist and a potential lead compound for further testing in the drug development process for aging-associated diseases.

5-Feruloylquinic acid

5-Feruloylquinic acid

Purity: 99.11%
Catalog No. TN1296Alias 5-O-Feruloylquinic acid, 5-FQACas No. 40242-06-6
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist and a potential lead compound for further testing in the drug development process for aging-associated diseases.
Pack SizePriceAvailabilityQuantity
1 mg$163In Stock
5 mg$328In Stock
10 mg$519In Stock
25 mg$832In Stock
50 mg$1,199In Stock
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Purity:99.11%
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Product Introduction

Bioactivity
Description
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist and a potential lead compound for further testing in the drug development process for aging-associated diseases.
In vitro
Traditional Chinese Medicine (TCM) compounds were employed for screening potent Sirt1 agonists, and molecular dynamics (MD) simulation was implemented to simulate ligand optimum docking poses and protein structure under dynamic conditions. TCM compounds such as (S)-tryptophan-betaxanthin, 5-O-Feruloylquinic acid, and RosA exhibited good binding affinity across different computational methods, and their drug-like potential were validated by MD simulation. Docking poses indicate that the carboxylic group of the three candidates generated H-bonds with residues in the protein chain from Ser441 to Lys444 and formed H-bond, π-cation interactions, or hydrophobic contacts with Phe297 and key active residue, His363. During MD, stable π-cation interactions with residues Phe273 or Arg274 were formed by (S)-tryptophan-betaxanthin and RosA[1].
Alias5-O-Feruloylquinic acid, 5-FQA
Chemical Properties
Molecular Weight368.34
FormulaC17H20O9
Cas No.40242-06-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 33.33 mg/mL (90.50 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7149 mL13.5744 mL27.1488 mL135.7441 mL
5 mM0.5430 mL2.7149 mL5.4298 mL27.1488 mL
10 mM0.2715 mL1.3574 mL2.7149 mL13.5744 mL
20 mM0.1357 mL0.6787 mL1.3574 mL6.7872 mL
50 mM0.0543 mL0.2715 mL0.5430 mL2.7149 mL

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