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5-BDBD
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.
Catalog No. T22518Cas No. 768404-03-1
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Purity:97.78%
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5-BDBD
Catalog No. T22518Cas No. 768404-03-1
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 2 mg | $52 | In Stock | |
| 5 mg | $84 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $322 | In Stock | |
| 50 mg | $572 | In Stock | |
| 100 mg | $815 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. |
| Targets&IC50 | P2X4:0.75 μM |
| In vitro | 5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1]. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1]. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1]. |
| In vivo | Basal hyperalgesia induced by recurrent NTG injection was completely blocked by 5-BDBD[2]. |
| Animal Research | 5-BDBD (28 mg/kg; i.p.; daily for 9 days; male C57BL/6 mice) prevented NTG-induced mechanical hypersensitivity[2]. |
| Molecular Weight | 355.19 |
| Formula | C17H11BrN2O2 |
| Cas No. | 768404-03-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (168.92 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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