Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 31.00 | |
50 mg | In stock | $ 46.00 | |
100 mg | In stock | $ 66.00 | |
500 mg | In stock | $ 83.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | 6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
In vivo | Phosphoribosyl pyrophosphate amidotransferase acts as the rate-limiting enzyme in purine biosynthesis, affecting the synthesis and function of RNA and DNA. Mercaptopurine inhibits this enzyme, thereby hindering purine nucleoside and its metabolism, which interferes with nucleotide interconversion and glycoprotein synthesis. |
Synonyms | 6-MP, Mercaptopurine |
Molecular Weight | 152.18 |
Formula | C5H4N4S |
CAS No. | 50-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28 mg/mL (184 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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6-Mercaptopurine 50-44-2 Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Others Endogenous Metabolite Dehydrogenase Nucleoside Antimetabolite/Analog Inhibitor 6 Mercaptopurine 6-MP 6Mercaptopurine Mercaptopurine inhibit inhibitor