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6-Thioguanine

Catalog No. T3089   CAS 154-42-7
Synonyms: 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine, Thioguanine

6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

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6-Thioguanine Chemical Structure
6-Thioguanine, CAS 154-42-7
Pack Size Availability Price/USD Quantity
50 mg In stock $ 40.00
100 mg In stock $ 48.00
500 mg In stock $ 72.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 98.75%
Purity: 98.34%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50 Plpro:25 μM, USP2:40 μM
Synonyms 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine, Thioguanine
Molecular Weight 167.19
Formula C5H5N5S
CAS No. 154-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14 mg/mL (83.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Krynetskaia NF, et al. FASEB J, 2000, 14(14), 2339-2344. 2. Marathias VM, et al. Nucleic Acids Res,1999, 27(14), 2860-2867. 3. Yamane K, et al. Clin Cancer Res,2005, 11(6), 2355-2363. 4. Brem R, et al. Photochem Photobiol,2012, 88(1), 5-13. 5. Issaeva N, et al. Cancer Res,2010, 70(15), 6268-6276. 6. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55. 7. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.

TargetMolCitations

1. Łagosz-Ćwik K, Melnykova M, Nieboga E, et al.Mapping of DNA methylationsensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis.Frontiers in Immunology.2023, 14.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library FDA-Approved & Pharmacopeia Drug Library Orally Active Compound Library Cell Cycle Compound Library HIF-1 Signaling Pathway Compound Library Toxic Compound Library Covalent Inhibitor Library

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Keywords

6-Thioguanine 154-42-7 Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Ubiquitination Endogenous Metabolite SARS-CoV DNA Methyltransferase DUB 6-TG 6 Thioguanine SARS coronavirus Deubiquitinase DUBs DNMTs inhibit DNA MTases 2-Amino-6-purinethiol Inhibitor 2-Amino-6-mercaptopurine Thioguanine 6Thioguanine inhibitor

 

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