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A-867744

Catalog No. TQ0117 CAS 1000279-69-5

A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).

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A-867744, CAS 1000279-69-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 193.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 519.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 95.66%

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Description	A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
Targets&IC50	α7 nAChR:1.0 μM (EC50)
In vitro	A-867744(Compound 19), a novel type II PAM with good potency and selectivity.?Compound 19 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs.?In a rodent model of sensory gating, 19 normalized gating deficits.?These results suggest that 19 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs[2].

Molecular Weight	402.89
Formula	C20H19ClN2O3S
CAS No.	1000279-69-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (248.21 mM)

References and Literature

1. Malysz J, et al. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. 2. Faghih R, et al. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2009 May 28;52(10):3377-84.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Autophagy Compound Library Bioactive Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Anti-Alzheimer's Disease Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

A-867744 1000279-69-5 Autophagy Neuroscience AChR Inhibitor inhibit nAChR A 867744 Nicotinic acetylcholine receptors A867744 inhibitor

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