Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 313.00 | |
100 mg | In stock | $ 493.00 | |
500 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 74.00 |
Description | AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor. |
Targets&IC50 | SIRT2:3.5 μM |
In vitro | In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3] |
In vivo | In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1] |
Molecular Weight | 434.27 |
Formula | C23H13Cl2N3O2 |
CAS No. | 304896-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.3 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AGK2 304896-28-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin AGK-2 inhibit AGK 2 Inhibitor inhibitor