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AGK2
🥰Excellent
Catalog No. T6371Cas No. 304896-28-4
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
AGK2
🥰Excellent
Purity: 99.17%
Catalog No. T6371Cas No. 304896-28-4
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $41 | In Stock | |
| 5 mg | $67 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $313 | In Stock | |
| 100 mg | $493 | In Stock | |
| 500 mg | $1,090 | In Stock |
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Purity:99.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor. |
| Targets&IC50 | SIRT2:3.5 μM |
| In vitro | In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3] |
| In vivo | In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1] |
| Molecular Weight | 434.27 |
| Formula | C23H13Cl2N3O2 |
| Cas No. | 304896-28-4 |
| Smiles | Clc1ccc(Cl)c(c1)-c1ccc(C=C(C#N)C(=O)Nc2cccc3ncccc23)o1 |
| Relative Density. | 1.445 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.3 mg/mL (10 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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