Powder: -20°C for 3 years | In solvent: -80°C for 1 year
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 595.00 | |
100 mg | In stock | $ 866.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. |
Targets&IC50 | NOX2:0.57 μM (ki), Nox4:0.63 μM (ki), NOX1:ki:1.08 μM |
In vitro | In the mouse podocyte cell line, APX-115 free base (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 free base attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2]. |
In vivo | APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. |
Synonyms | Ewha-18278 free base |
Molecular Weight | 279.34 |
Formula | C17H17N3O |
CAS No. | 1270084-92-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (877.07 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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APX-115 free base 1270084-92-8 Immunology/Inflammation Metabolism NADPH-oxidase NADPH plasma APX 115 free base NOX Inhibitor injury Nox1 kidney Ewha18278 albumin Ewha 18278 APX115 free base Ewha-18278 insulin APX115 Nox3 resistance APX-115 NADPH Oxidase inhibit Ewha-18278 free base APX 115 creatinine Nox2 inhibitor