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Cytoskeletal Signaling Akt AT13148

AT13148

Catalog No. T2482   CAS 1056901-62-2
Purity 98.04% Datasheet MSDS

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

AT13148, CAS 1056901-62-2
Pack Size Availability Price/USD Quantity
2 mg In stock 64.00
5 mg In stock 129.00
10 mg In stock 231.00
25 mg In stock 398.00
50 mg In Stock 562.00
100 mg In Stock 797.00
1 mL * 10 mM (in DMSO) In stock 149.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Targets&IC50 Akt1 :ic50 38nM,   Akt2 :ic50 402nM,   Akt3 :ic50 50nM,   p70 S6K :ic50 8nM,   PKA :ic50 3nM,   ROCK1 :ic50 6nM,   ROCK2 :ic50 4nM,   RSK1 :ic50 85nM,   SGK3 :ic50 63nM,  
Kinase Assay In vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme.
Cell Research
Cytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference)
Cell lines: MES-SA, MES-SA/Dx5, BT474, HCT-116, A549, PC3, SK-BR-3, MCF7, U87MG, MDA-MB-468, DU-145, and SK-OV-3 cell lines
Animal Research
Animal Model: Athymic mice bearing MES-SA, BT474, or PC3 tumor xenografts
Synonyms
Purity 98.00%
Appearance solid
Molecular Weight 313.78
Formula C17H16ClN3O
CAS No. 1056901-62-2

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 58 mg/mL (184.8 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Yap TA, et al. Clin Cancer Res. 2012, 18(14), 3912-3923. 2. Xi Y, et al. AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-6.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Stem cell Differentiation Compound Library PI3K-AKT-mTOR Compound Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Cell cycle related Compound Library

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