store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 165.00 | |
10 mg | In stock | $ 243.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 597.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 195.00 |
Description | AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies. |
Targets&IC50 | CDK9:4 nM (IC50) |
In vitro | Short-term administration of AZD4573 induced a swift, dose- and time-dependent reduction in cellular pSer2-RNAPII levels, which in turn activated caspase 3, leading to apoptosis across a wide spectrum of hematological cancer cell lines. Notably, caspase activation exhibited an EC50 of 13.7 nM in the acute myeloid leukemia model MV4-11. |
In vivo | AZD4573 exhibits a short half-life in multiple species (less than one hour in dog, rat, and monkey) and good solubility for intravenous administration. |
Molecular Weight | 429.94 |
Formula | C22H28ClN5O2 |
CAS No. | 2057509-72-3 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (290.74 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD4573 2057509-72-3 Cell Cycle/Checkpoint CDK inhibit Inhibitor AZD-4573 AZD 4573 Cyclin dependent kinase inhibitor