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AZD7624

Catalog No. T14381 CAS 1095004-78-6

Synonyms: AZD-7624

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AZD7624, CAS 1095004-78-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
Targets&IC50	TNFα:8.4(human mononuclear cells), 8.1(whole blood), 9.0 (alveolar macrophages)
In vitro	AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50s of 8.4, 8.1, and 9.0[1]. AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

Synonyms	AZD-7624
Molecular Weight	491.56
Formula	C27H30FN5O3
CAS No.	1095004-78-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (101.72 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365(3):567-572.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZD7624 1095004-78-6 Apoptosis MAPK TNF p38 MAPK Inhibitor inhibit Autophagy AZD 7624 AZD-7624 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.