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Alectinib

Catalog No. T1936   CAS 1256580-46-7
Synonyms: RG-7853, AF802, CH5424802, AF-802

Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.

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Alectinib Chemical Structure
Alectinib, CAS 1256580-46-7
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 63.00
10 mg In stock $ 79.00
50 mg In stock $ 107.00
100 mg In stock $ 171.00
200 mg In stock $ 273.00
500 mg In stock $ 459.00
1 mL * 10 mM (in DMSO) In stock $ 67.00
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Purity: 99.97%
Purity: 99.27%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
Targets&IC50 ALK:1.9 nM, ALK (R1275Q):3.5 nM, ALK (F1174L):1 nM
Kinase Assay Kinase inhibitory assays in Vitro: The inhibitory ability against each kinase except for MEK1 and Raf-1 is evaluated by examining their ability to phosphorylate various substrate peptides in the presence of CH5424802 using time-resolved fluorescence resonance energy transfer (TR-FRET) assay or fluorescence polarization (FP) assay. The inhibitory activity against MEK1 is evaluated by quantitative analysis of the phosphorylation of a substrate peptide by a recombinant ERK2 protein in the presence of CH5424802. The inhibitory activity against Raf-1 is evaluated by examining the ability of the kinases to phosphorylate MEK1 in the presence of CH5424802.
Cell Research Cells including NSCLC, A549 and HCC827 are seeded in 96-well plates overnight and incubated with various concentrations of CH5424802 for the indicated time. For spheroid cell growth inhibition assay, cells are seeded on spheroid plates, incubated overnight, and then treated with compound for the indicated times. The viable cells are measured by the Luminescent Cell Viability Assay. Caspase-3/7 assay is evaluated using the Caspase-Glo 3/7 Assay Kit.(Only for Reference)
Synonyms RG-7853, AF802, CH5424802, AF-802
Molecular Weight 482.62
Formula C30H34N4O2
CAS No. 1256580-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 2.1 mM

DMSO: 4.83 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Sakamoto H, et al. Cancer Cell. 2011, 19(5), 679-690. 2. Kinoshita K, et al. Bioorg Med Chem. 2012, 20(3), 1271-1280.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Lung Cancer Compound Library

Related Products

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Vidarabine Cerdulatinib Hypericin Filgotinib Syk Inhibitor II dihydrochloride Ilginatinib hydrochloride Gefitinib GLPG0634 analog

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Keywords

Alectinib 1256580-46-7 Angiogenesis Tyrosine Kinase/Adaptors VEGFR Tyrosine Kinases ALK ALK tyrosine kinase receptor RO-5424802 RO5424802 Anaplastic lymphoma kinase CD246 RG-7853 RG 7853 inhibit RG7853 AF802 CH5424802 Inhibitor CH 5424802 AF 802 Cluster of differentiation 246 Anaplastic lymphoma kinase (ALK) AF-802 RO 5424802 CH-5424802 inhibitor

 

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