Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 79.00 | |
50 mg | In stock | $ 107.00 | |
100 mg | In stock | $ 171.00 | |
200 mg | In stock | $ 273.00 | |
500 mg | In stock | $ 459.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 67.00 |
Description | Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. |
Targets&IC50 | ALK:1.9 nM, ALK (R1275Q):3.5 nM, ALK (F1174L):1 nM |
Kinase Assay | Kinase inhibitory assays in Vitro: The inhibitory ability against each kinase except for MEK1 and Raf-1 is evaluated by examining their ability to phosphorylate various substrate peptides in the presence of CH5424802 using time-resolved fluorescence resonance energy transfer (TR-FRET) assay or fluorescence polarization (FP) assay. The inhibitory activity against MEK1 is evaluated by quantitative analysis of the phosphorylation of a substrate peptide by a recombinant ERK2 protein in the presence of CH5424802. The inhibitory activity against Raf-1 is evaluated by examining the ability of the kinases to phosphorylate MEK1 in the presence of CH5424802. |
Cell Research | Cells including NSCLC, A549 and HCC827 are seeded in 96-well plates overnight and incubated with various concentrations of CH5424802 for the indicated time. For spheroid cell growth inhibition assay, cells are seeded on spheroid plates, incubated overnight, and then treated with compound for the indicated times. The viable cells are measured by the Luminescent Cell Viability Assay. Caspase-3/7 assay is evaluated using the Caspase-Glo 3/7 Assay Kit.(Only for Reference) |
Synonyms | RG-7853, AF802, CH5424802, AF-802 |
Molecular Weight | 482.62 |
Formula | C30H34N4O2 |
CAS No. | 1256580-46-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2.1 mM
DMSO: 4.83 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Alectinib 1256580-46-7 Angiogenesis Tyrosine Kinase/Adaptors VEGFR Tyrosine Kinases ALK ALK tyrosine kinase receptor RO-5424802 RO5424802 Anaplastic lymphoma kinase CD246 RG-7853 RG 7853 inhibit RG7853 AF802 CH5424802 Inhibitor CH 5424802 AF 802 Cluster of differentiation 246 Anaplastic lymphoma kinase (ALK) AF-802 RO 5424802 CH-5424802 inhibitor